Unknown

Dataset Information

0

Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans.


ABSTRACT: The live-attenuated Yellow Fever (YF) vaccine YF-17D induces a broad and polyfunctional CD8 T cell response in humans. Recently, we identified a population of stem cell-like memory CD8 T cells induced by YF-17D that persists at stable frequency for at least 25 years after vaccination. The YF-17D is thus a model system of human CD8 T cell biology that furthermore allows to track and study long-lasting and antigen-specific human memory CD8 T cells. Here, we describe in detail the sample characteristics and preparation of a microarray dataset acquired for genome-wide gene expression profiling of long-lasting YF-specific stem cell-like memory CD8 T cells, compared to the reference CD8 T cell differentiation subsets from total CD8 T cells. We also describe the quality controls, annotations and exploratory analyses of the dataset. The microarray data is available from the Gene Expression Omnibus (GEO) public repository with accession number GSE65804.

PROVIDER: S-EPMC4583680 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC3374958 | BioStudies
| S-EPMC4071376 | BioStudies
| S-EPMC4757529 | BioStudies
| S-EPMC2118210 | BioStudies
| S-EPMC4297749 | BioStudies
2017-12-13 | GSE26347 | GEO
| S-EPMC4442358 | BioStudies
2022-05-05 | GSE148223 | GEO
| S-EPMC4048998 | BioStudies
| S-EPMC4792480 | BioStudies