Dataset Information


Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.

ABSTRACT: Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyelitis (EAE) mice, pGSN concentration increased in the EAE brain. Recombinant human pGSN (rhp-GSN) decreased extracellular actin and myeloperoxidase activity in the brain, resulting in reduced disease activity and less severe clinical disease, suggesting that gelsolin could be a potential therapeutic target for MS.

SUBMITTER: Li-ChunHsieh K 

PROVIDER: S-EPMC4595933 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC6120956 | BioStudies
2020-01-01 | S-EPMC7018662 | BioStudies
1000-01-01 | S-EPMC5428824 | BioStudies
2020-01-01 | S-EPMC7583768 | BioStudies
2020-01-01 | S-EPMC7563380 | BioStudies
2014-01-01 | S-EPMC4247973 | BioStudies
2016-01-01 | S-EPMC4720725 | BioStudies
2020-01-01 | S-EPMC7177774 | BioStudies
1000-01-01 | S-EPMC2678046 | BioStudies
1000-01-01 | S-EPMC4132929 | BioStudies