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Rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.


ABSTRACT: We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

SUBMITTER: Rasmussen-Torvik LJ 

PROVIDER: S-EPMC4598314 | BioStudies | 2015-01-01

SECONDARY ACCESSION(S): rs4771122

REPOSITORIES: biostudies

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