Unknown

Dataset Information

0

Detection of airborne viruses using electro-aerodynamic deposition and a field-effect transistor.


ABSTRACT: We report a technique for the detection of aerosolized viruses. Conventional field-effect-transistor (FET)-based techniques use solution-based processes, thus require antibody binding to the detection region of the FET prior to the supply of the analyte. With the method described here, virus-antibody-bound particles are delivered to the FET during detection; therefore, neither a pre-treatment antibody binding step on the FET channel nor washing process for virus-antibody-binding are necessary. Our method is based on the concept that virus-antibody-bound particles are larger than the virus or antibody alone, and thus have larger charge numbers following aerosol charging. When these particles are charged by negative ions and electro-aerodynamically deposited on a substrate, there exists a location on the substrate where neither lone virus nor antibody particles land, and where only virus-antibody-bound particles are deposited. If this location coincides with the channel of the FET, the resulting variation in the current can be used to indicate the existence of a virus. By aerosolizing a mixed solution of the virus and the antibody, only the virus-antibody-bound particles were transported to the swCNT-FET, and the electric current in the swCNT-FET decreased to 30% of that measured with no deposited particles.

SUBMITTER: Park KT 

PROVIDER: S-EPMC4672335 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC5738443 | BioStudies
1000-01-01 | S-EPMC4273243 | BioStudies
2013-01-01 | S-EPMC3728521 | BioStudies
2014-01-01 | S-EPMC5453370 | BioStudies
1000-01-01 | S-EPMC4419583 | BioStudies
2020-01-01 | S-EPMC7339189 | BioStudies
2015-01-01 | S-EPMC4652105 | BioStudies
2010-01-01 | S-EPMC3140212 | BioStudies
1000-01-01 | S-EPMC4466106 | BioStudies
2016-01-01 | S-EPMC4773239 | BioStudies