Unknown

Dataset Information

0

Hepatitis C virus: why do we need a vaccine to prevent a curable persistent infection?


ABSTRACT: Chronic hepatitis C virus infection is now curable by antiviral therapy but the global burden of liver disease is unlikely to diminish without a vaccine to prevent transmission. The objective of HCV vaccination is not to induce sterilizing immunity, but instead to prevent persistent infection. One vaccine that incorporates only non-structural HCV proteins is now in phase I/II efficacy trials to test the novel concept that T cell priming alone is sufficient for protection. Evidence also suggests that antibodies contribute to infection resolution. Vaccines comprised of recombinant envelope glycoproteins targeted by neutralizing antibodies have been assessed in humans for immunogenicity. Here, we discuss current concepts in protective immunity and divergent approaches to vaccination against a highly mutable RNA virus.

SUBMITTER: Walker CM 

PROVIDER: S-EPMC4680967 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7296151 | BioStudies
2017-01-01 | S-EPMC5615075 | BioStudies
2020-01-01 | S-EPMC7338099 | BioStudies
2018-01-01 | S-EPMC6552668 | BioStudies
2013-01-01 | S-EPMC3884684 | BioStudies
2016-01-01 | S-EPMC5041021 | BioStudies
2004-01-01 | S-EPMC514466 | BioStudies
2017-01-01 | S-EPMC5763905 | BioStudies
2018-01-01 | S-EPMC5827382 | BioStudies
2019-01-01 | S-EPMC6543710 | BioStudies