Radical-mediated ring contraction in the biosynthesis of 7-deazapurines.
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ABSTRACT: Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
SUBMITTER: Bandarian V
PROVIDER: S-EPMC4753066 | BioStudies | 2015-01-01
SECONDARY ACCESSION(S): 4NJG
REPOSITORIES: biostudies
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