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Radical-mediated ring contraction in the biosynthesis of 7-deazapurines.


ABSTRACT: Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.

SUBMITTER: Bandarian V 

PROVIDER: S-EPMC4753066 | BioStudies | 2015-01-01

SECONDARY ACCESSION(S): 4NJG

REPOSITORIES: biostudies

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