Unknown

Dataset Information

0

Transcriptome sequencing of hematopoietic stem cells and chronic myelgenous leukemia stem cells.


ABSTRACT: Dipeptide species are accumulated in the chronic myelogenous leukemia (CML) stem cells [1]. To investigate the molecular mechanisms of the accumulation of dipeptide species in CML stem cells, we performed transcriptome sequencing of long-term stem cells, short-term stem cells, progenitor cells from healthy control and CML-affected mice (GSE70031). The transcriptome data revealed that the expression of a dipeptide transporter (solute carrier family 15, member 2 (SLC15A2)) was elevated only in the CML stem cells. This result indicates that dipeptide species accumulates in CML stem cells through a dipeptide transporter SLC15A2.

PROVIDER: S-EPMC4778595 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC4560789 | BioStudies
| S-EPMC6934217 | BioStudies
| S-EPMC2873971 | BioStudies
| S-EPMC3332001 | BioStudies
| S-EPMC7782553 | BioStudies
| S-EPMC7499193 | BioStudies
| S-EPMC2946231 | BioStudies
| E-GEOD-20359 | BioStudies
| S-EPMC2626150 | BioStudies
| S-EPMC7452122 | BioStudies