Unknown

Dataset Information

0

Crystal structures of four chiral imine-substituted thio-phene derivatives.


ABSTRACT: A series of thio-phenes substituted in positions 2 and 5 by imine groups have been synthesized using a solvent-free approach, and their crystal structures determined. The substituents are chiral groups, and the expected absolute configuration for each mol-ecule was confirmed by refinement of the Flack parameter. The compounds are 2,5-bis-[(S)-(+)-(1,2,3,4-tetra-hydro-naphthalen-1-yl)imino]-thio-phene, C26H26N2S, (I), 2,5-bis-{[(R)-(-)-1-(4-meth-oxy-phen-yl)eth-yl]imino-meth-yl}thio-phene, C24H26N2O2S, (II), 2,5-bis-{[(R)-(-)-1-(4-fluoro-phen-yl)eth-yl]imino-meth-yl}thio-phene, C22H20F2N2S, (III), and 2,5-bis-{[(S)-(+)-1-(4-chloro-phen-yl)eth-yl]imino-meth-yl}thio-phene, C22H20Cl2N2S, (IV). A common feature of all four mol-ecules is the presence of twofold symmetry. For (I), which crystallizes in the triclinic space group P1, this symmetry is non-crystallographic, but for (II) in C2 and the isomorphous structures (III) and (IV) that crystallize in P21212, the twofold symmetry is crystallographically imposed with one half of each mol-ecule in the asymmetric unit. The comparable mol-ecular symmetry in the four structures is also reflected in similar packing, with mol-ecules aggregated to form chains through weak C-H?S inter-actions.

PROVIDER: S-EPMC4778840 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC3009092 | BioStudies
1000-01-01 | S-EPMC4910349 | BioStudies
1000-01-01 | S-EPMC4331852 | BioStudies
| S-EPMC4908540 | BioStudies
1000-01-01 | S-EPMC4908520 | BioStudies
2011-01-01 | S-EPMC3051500 | BioStudies
1000-01-01 | S-EPMC5290543 | BioStudies
| S-EPMC3201550 | BioStudies
2019-01-01 | S-EPMC6659342 | BioStudies
1000-01-01 | S-EPMC3008090 | BioStudies