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Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids.


ABSTRACT: Feeding a modified fish diet has been suggested to improve insulin sensitivity in bottlenose dolphins; however, insulin sensitivity was not directly measured. Since demonstrating an improvement in insulin sensitivity is technically difficult in dolphins, we postulated that directional changes in the hormone axis: fibroblast growth factor 21 (FGF21)/Adiponectin/Ceramide (Cer), could provide further support to this hypothesis. We measured 2-h post-prandial serum FGF21, total adiponectin, percent unmodified adiponectin, ceramide, and sphingosine levels from dolphins fed a diet rich in heptadecanoic acid (C17:0) over 24?weeks. Serum FGF21 was quantified by ELISA with an observed range of 129-1599?pg/ml, but did not significantly change over the 24-week study period. Total adiponectin levels (mean?±?SD) significantly increased from 776?±?400?pmol/ml at week 0 to 1196?±?467?pmol/ml at week 24. The percent unmodified adiponectin levels (mean?±?SD) decreased from 23.8?±?6.0% at week 0?to?15.2?±?5.2% at week 24. Interestingly, although FGF21 levels did not change, there was a good correlation between FGF21 and total adiponectin (??=?0.788, P?

SUBMITTER: Sobolesky PM 

PROVIDER: S-EPMC4838613 | BioStudies | 2016-01-01

REPOSITORIES: biostudies

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