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Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.


ABSTRACT: Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 ?M) towards an osteosarcoma cell line.

SUBMITTER: Feng Z 

PROVIDER: S-EPMC4855835 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

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