Dataset Information


Functional joint regeneration is achieved using reintegration mechanism in Xenopus laevis.

ABSTRACT: A functional joint requires integration of multiple tissues: the apposing skeletal elements should form an interlocking structure, and muscles should insert into skeletal tissues via tendons across the joint. Whereas newts can regenerate functional joints after amputation, Xenopus laevis regenerates a cartilaginous rod without joints, a "spike." Previously we reported that the reintegration mechanism between the remaining and regenerated tissues has a significant effect on regenerating joint morphogenesis during elbow joint regeneration in newt. Based on this insight into the importance of reintegration, we amputated frogs' limbs at the elbow joint and found that frogs could regenerate a functional elbow joint between the remaining tissues and regenerated spike. During regeneration, the regenerating cartilage was partially connected to the remaining articular cartilage to reform the interlocking structure of the elbow joint at the proximal end of the spike. Furthermore, the muscles of the remaining part inserted into the regenerated spike cartilage via tendons. This study might open up an avenue for analyzing molecular and cellular mechanisms of joint regeneration using Xenopus.

SUBMITTER: Tsutsumi R 

PROVIDER: S-EPMC4857750 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4895332 | BioStudies
2020-01-01 | S-EPMC7052906 | BioStudies
2012-01-01 | S-EPMC3501998 | BioStudies
2019-01-01 | S-EPMC6363752 | BioStudies
2013-01-01 | S-EPMC3641891 | BioStudies
2012-01-01 | S-EPMC3503958 | BioStudies
2013-01-01 | S-EPMC4034586 | BioStudies
1000-01-01 | S-EPMC4497612 | BioStudies
1000-01-01 | S-EPMC6197768 | BioStudies
1000-01-01 | S-EPMC3713088 | BioStudies