Dataset Information


Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.

ABSTRACT: Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C(-/-)). Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-? promoter. We found that both NKG2C(-) and NKG2C(+) adaptive NK cells expressed high levels of CD2, which synergistically enhanced ERK and S6RP phosphorylation following CD16 ligation. Notably, CD2 co-stimulation was critical for the ability of adaptive NK cells to respond to antibody-coated target cells. These results reveal an unexpected redundancy in the human NK cell response to HCMV and suggest that CD2 provides "signal 2" in antibody-driven adaptive NK cell responses.


PROVIDER: S-EPMC4858565 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2014-01-01 | S-EPMC4348979 | BioStudies
2015-01-01 | S-EPMC4638145 | BioStudies
2019-01-01 | S-EPMC6456717 | BioStudies
2018-01-01 | S-EPMC5968376 | BioStudies
2020-01-01 | S-EPMC7057582 | BioStudies
2018-01-01 | S-EPMC5919961 | BioStudies
2017-01-01 | S-EPMC5660692 | BioStudies
2018-01-01 | S-EPMC5864861 | BioStudies
2015-01-01 | S-EPMC4594010 | BioStudies
2019-01-01 | S-EPMC6803486 | BioStudies