Unknown

Dataset Information

0

Prospective study of muscle cramps in Charcot-Marie-tooth disease.


ABSTRACT: This study aims to assess the frequency, location, severity, duration, and fluctuation over time of muscle cramps in Charcot-Marie-Tooth disease (CMT).Inherited Neuropathies Consortium Contact Registry participants recorded the occurrence and characteristics of muscle cramps using an 11-question survey administered 3 times over 8 weeks.A total of 110 adult patients with CMT completed the survey. Weekly cramp frequency was 9.3 (SD 12.3), and 23% had daily muscle cramps. Twenty-two percent reported a significant impact on quality of life. Over 8 weeks, the daily frequency and severity of muscle cramps did not change significantly.Patients with CMT have muscle cramps that vary little over an 8-week period, and they may interfere with quality of life. These data may be useful in the planning of clinical trials of agents to treat adults with CMT-associated muscle cramps.

SUBMITTER: Johnson NE 

PROVIDER: S-EPMC4860275 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5575819 | BioStudies
2018-01-01 | S-EPMC6126993 | BioStudies
2017-01-01 | S-EPMC6324187 | BioStudies
2018-01-01 | S-EPMC5949967 | BioStudies
1000-01-01 | S-EPMC1463087 | BioStudies
1000-01-01 | S-EPMC1463088 | BioStudies
2016-01-01 | S-EPMC4836879 | BioStudies
2012-01-01 | S-EPMC3444502 | BioStudies
2020-01-01 | S-EPMC7585892 | BioStudies
2016-01-01 | S-EPMC4775451 | BioStudies