Dataset Information


Association of glutathione S-transferase T1, M1, and P1 polymorphisms in the breast cancer risk: a meta-analysis.

ABSTRACT: Several case-control studies investigating the relationship between genetic polymorphisms of glutathione S-transferase (GST) M1, GSTT1, and GSTP1 (rs1695) and the risk of breast cancer have reported contradictory results. We therefore performed a meta-analysis to clarify this issue.An updated meta-analysis using PubMed and Web of Knowledge databases for the eligible case-control studies was performed. Random- or fixed-effects model was used.A total of 10,067 cancer cases and 12,276 controls in 41 independent case-control studies from 19 articles were included in this meta-analysis. Significant increase in risk of breast cancer for Asians was found in GSTM1-null genotype (P=0.012, odds ratio [OR] =1.17, 95% confidence interval [CI] =1.04-1.32) and GSTT1-null genotype (P=0.039, OR =1.19, 95% CI =1.01-1.41). In addition, our results showed that the GSTP1 (rs1695) polymorphisms can significantly increase the risk among Caucasians (P=0.042, OR =1.16, 95% CI =1.01-1.34). Sensitivity analysis and publication bias further confirmed the dependability of the results in this meta-analysis.Our results demonstrate that both GSTM1- and GSTT1-null polymorphisms are associated with an increased risk of breast cancer in Asians and that GSTP1 Val105Ile (rs1695) polymorphism is associated with an increased breast cancer risk in Caucasians.


PROVIDER: S-EPMC4869650 | BioStudies | 2016-01-01


REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7064184 | BioStudies
2013-01-01 | S-EPMC3786079 | BioStudies
2014-01-01 | S-EPMC4314001 | BioStudies
1000-01-01 | S-EPMC5993999 | BioStudies
2015-01-01 | S-EPMC4694490 | BioStudies
2012-01-01 | S-EPMC3506585 | BioStudies
2014-01-01 | S-EPMC4033138 | BioStudies
2014-01-01 | S-EPMC4160566 | BioStudies
2020-01-01 | S-EPMC7143748 | BioStudies
2010-01-01 | S-EPMC3074275 | BioStudies