Ontology highlight
ABSTRACT:
SUBMITTER: Tsai TT
PROVIDER: S-EPMC4899773 | BioStudies | 2016-01-01
SECONDARY ACCESSION(S): 10.1038/srep27670
REPOSITORIES: biostudies
Tsai Tsung-Ting TT Chen Chia-Ling CL Lin Yee-Shin YS Chang Chih-Peng CP Tsai Cheng-Chieh CC Cheng Yi-Lin YL Huang Chao-Ching CC Ho Chien-Jung CJ Lee Yi-Chao YC Lin Liang-Tzung LT Jhan Ming-Kai MK Lin Chiou-Feng CF
Scientific reports 20160609
Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompanied by CNS inflammation, neurotoxicity, and blood-brain barrier destruction. Microglial cells surrounding the blood vessels and injured hippocampus regions were activated by DENV i ...[more]