Unknown

Dataset Information

0

Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.


ABSTRACT: Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near-infrared dye IR-780 could be used as photosensitizer both for PTT and PDT, but its lipophilicity limits its practical use and in vivo efficiency. Herein, a simple multifunctional IR780-loaded nanoplatform based on transferrin was developed for targeted imaging and phototherapy of cancer compatible with a single-NIR-laser irradiation. The self-assembled transferrin-IR780 nanoparticles (Tf-IR780 NPs) exhibited narrow size distribution, good photo-stability, and encouraging photothermal performance with enhanced generation of ROS under laser irradiation. Following intravenous injection, Tf-IR780 NPs had a high tumor-to-background ratio in CT26 tumor-bearing mice. Treatment with Tf-IR780 NPs resulted in significant tumor suppression. Overall, the Tf-IR780 NPs show notable targeting and theranostic potential in cancer therapy.

PROVIDER: S-EPMC4899881 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC5722019 | BioStudies
2018-01-01 | S-EPMC5977361 | BioStudies
1000-01-01 | S-EPMC6359812 | BioStudies
| S-EPMC7472706 | BioStudies
2019-01-01 | S-EPMC6724470 | BioStudies
1000-01-01 | S-EPMC5118601 | BioStudies
2019-01-01 | S-EPMC6587161 | BioStudies
2015-01-01 | S-EPMC5226384 | BioStudies
2013-01-01 | S-EPMC4133987 | BioStudies
2018-01-01 | S-EPMC6096383 | BioStudies