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Taspase 1: A protease with many biological surprises.


ABSTRACT: Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a "non-oncogene addiction" protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

SUBMITTER: Niizuma H 

PROVIDER: S-EPMC4905357 | BioStudies | 2015-01-01

SECONDARY ACCESSION(S): 10.1080/23723556.2014.999513

REPOSITORIES: biostudies

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