Dataset Information


Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

ABSTRACT: Killer cell immunoglobulin-like receptor (KIR) genes encode for activating and inhibitory surface receptors, which are correlated with the regulation of Natural Killer (NK) cell cytotoxic activity. Reduced NK cell cytotoxic activity has been consistently reported in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients, and KIR haplotypes and allelic polymorphism remain to be investigated. The aim of this article was to conduct a pilot study to examine KIR genotypes, haplotypes, and allelic polymorphism in CFS/ME patients and nonfatigued controls (NFCs). Comparison of KIR and allelic polymorphism frequencies revealed no significant differences between 20 CFS/ME patients and 20 NFCs. A lower frequency of the telomeric A/B motif (P < 0.05) was observed in CFS/ME patients compared with NFCs. This pilot study is the first to report the differences in the frequency of KIR on the telomeric A/B motif in CFS/ME patients. Further studies with a larger CFS/ME cohort are required to validate these results.


PROVIDER: S-EPMC4913894 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5437120 | BioStudies
2020-01-01 | S-EPMC7072752 | BioStudies
2013-01-01 | S-EPMC3557723 | BioStudies
2017-01-01 | S-EPMC5609756 | BioStudies
2006-01-01 | S-EPMC2118260 | BioStudies
2018-01-01 | S-EPMC6046604 | BioStudies
2013-01-01 | S-EPMC3814319 | BioStudies
2019-01-01 | S-EPMC6749077 | BioStudies
2017-01-01 | S-EPMC5729331 | BioStudies
2011-01-01 | S-EPMC3490103 | BioStudies