Unknown

Dataset Information

0

Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images.


ABSTRACT: Drug and alcohol abusers develop strong memories for drug-related stimuli. Preclinical studies suggest that such memories are a result of drug actions on reward pathways, which facilitate learning about drug-related stimuli. However, few controlled studies have investigated how drugs affect memory for drug-related stimuli in humans.The current study examined the direct effect of alcohol on memory for images of alcohol-related or neutral beverages. Participants received alcohol (0.8 g/kg) either before viewing visual images (encoding condition; n = 20) or immediately after viewing them (consolidation condition; n = 20). A third group received placebo both before and after viewing the images (control condition; n = 19). Memory retrieval was tested exactly 48 hours later, in a drug-free state.Alcohol impaired memory in the encoding condition and enhanced memory in the consolidation condition, but these effects did not differ for alcohol-related and neutral beverage stimuli. However, in the encoding condition, participants who experienced greater alcohol-induced stimulation exhibited better memory for alcohol-related, but not neutral beverage stimuli.These findings suggest that individual differences in sensitivity to the positive, rewarding effects of alcohol are associated with greater propensity to remember alcohol-related stimuli encountered while intoxicated. As such, stimulant responders may form stronger memory associations with alcohol-related stimuli, which might then influence their drinking behavior.

SUBMITTER: Weafer J 

PROVIDER: S-EPMC4930409 | BioStudies | 2016-01-01

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4435500 | BioStudies
2015-01-01 | S-EPMC4332474 | BioStudies
2014-01-01 | S-EPMC4253872 | BioStudies
2020-01-01 | S-EPMC7079052 | BioStudies
2010-01-01 | S-EPMC2955848 | BioStudies
1000-01-01 | S-EPMC3055670 | BioStudies
2009-01-01 | S-EPMC2742172 | BioStudies
2016-01-01 | S-EPMC4951131 | BioStudies
1000-01-01 | S-EPMC3501972 | BioStudies
2014-01-01 | S-EPMC4221216 | BioStudies