Dataset Information


Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.

ABSTRACT: DREADDs, designer receptors exclusively activated by designer drugs, are engineered G protein-coupled receptors (GPCR) which can precisely control GPCR signaling pathways (for example, Gq, Gs, and Gi). This chemogenetic technology for control of GPCR signaling has been successfully applied in a variety of in vivo studies, including in mice, to remotely control GPCR signaling, for example, in neurons, glia cells, pancreatic ?-cells, or cancer cells. In order to fully explore the in vivo applications of the DREADD technology, we generated hM3Dq and hM4Di strains of mice which allow for Cre recombinase-mediated restricted expression of these pathway-selective DREADDs. With the many Cre driver lines now available, these DREADD lines will be applicable to studying a wide array of research and preclinical questions. genesis 54:439-446, 2016. © 2016 Wiley Periodicals, Inc.


PROVIDER: S-EPMC4990490 | BioStudies | 2016-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6407913 | BioStudies
2015-01-01 | S-EPMC4368042 | BioStudies
2020-01-01 | S-EPMC7500623 | BioStudies
2020-01-01 | S-EPMC7071376 | BioStudies
2017-01-01 | S-EPMC7309169 | BioStudies
2020-01-01 | S-EPMC7318895 | BioStudies
2016-01-01 | S-EPMC5083007 | BioStudies
2017-01-01 | S-EPMC5394278 | BioStudies
2020-01-01 | S-EPMC7259531 | BioStudies
2019-01-01 | S-EPMC6788984 | BioStudies