Unknown

Dataset Information

0

Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans.


ABSTRACT: DAF-16, the C. elegans FOXO transcription factor, is an important determinant in aging and longevity. In this work, we manually curated FOXODB http://lyh.pkmu.cn/foxodb/, a database of FOXO direct targets. It now covers 208 genes. Bioinformatics analysis on 109 DAF-16 direct targets in C. elegans found interesting results. (i) DAF-16 and transcription factor PQM-1 co-regulate some targets. (ii) Seventeen targets directly regulate lifespan. (iii) Four targets are involved in lifespan extension induced by dietary restriction. And (iv) DAF-16 direct targets might play global roles in lifespan regulation.

SUBMITTER: Li YH 

PROVIDER: S-EPMC4991374 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3763726 | BioStudies
2008-01-01 | S-EPMC2350227 | BioStudies
2014-01-01 | S-EPMC4022319 | BioStudies
1000-01-01 | S-EPMC3824081 | BioStudies
2011-01-01 | S-EPMC3164695 | BioStudies
2015-01-01 | S-EPMC4747164 | BioStudies
2018-01-01 | S-EPMC6089956 | BioStudies
1000-01-01 | S-EPMC3691573 | BioStudies
2012-01-01 | S-EPMC3420913 | BioStudies
2007-01-01 | S-EPMC2185793 | BioStudies