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Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.

ABSTRACT: Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.

PROVIDER: S-EPMC5030165 | BioStudies |

REPOSITORIES: biostudies

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