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Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots.


ABSTRACT: Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information.

SUBMITTER: Hirata Y 

PROVIDER: S-EPMC5057099 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

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