Dataset Information


The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice.

ABSTRACT: Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous fat thickness varied positively with fat intake, due to enlarged adipocytes rather than increased adipocyte number. We therefore demonstrated clear interactions between skin structure and macronutrient intakes, with the associations being sex-specific and dependent on dietary macronutrient balance.


PROVIDER: S-EPMC5104383 | BioStudies | 2016-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6927877 | BioStudies
2015-01-01 | S-EPMC4425145 | BioStudies
2015-01-01 | S-EPMC4410498 | BioStudies
2018-01-01 | S-EPMC6298787 | BioStudies
2020-01-01 | S-EPMC7190059 | BioStudies
2011-01-01 | S-EPMC3127525 | BioStudies
2013-01-01 | S-EPMC3518205 | BioStudies
1000-01-01 | S-EPMC6115811 | BioStudies
2017-01-01 | S-EPMC5494266 | BioStudies
2013-01-01 | S-EPMC3652928 | BioStudies