Dataset Information


Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats.

ABSTRACT: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.


PROVIDER: S-EPMC5216641 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4819864 | BioStudies
2015-01-01 | S-EPMC4581730 | BioStudies
2019-01-01 | S-EPMC6764500 | BioStudies
2008-01-01 | S-EPMC2621409 | BioStudies
2018-01-01 | S-EPMC5757986 | BioStudies
2012-01-01 | S-EPMC3349760 | BioStudies
2020-01-01 | S-EPMC7301449 | BioStudies
2018-01-01 | S-EPMC5852855 | BioStudies
1000-01-01 | S-EPMC4016123 | BioStudies
2019-01-01 | S-EPMC7001751 | BioStudies