Unknown

Dataset Information

0

Divergent prion strain evolution driven by PrPC expression level in transgenic mice.


ABSTRACT: Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrPC into PrPSc. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Constrained interactions between PrPC and different PrPSc strains can in turn lead to certain PrPSc (sub)populations being selected for cross-species transmission, or even produce mutation-like events. By contrast, prion strains are generally conserved when transmitted within the same species, or to transgenic mice expressing homologous PrPC. Here, we compare the strain properties of a representative sheep scrapie isolate transmitted to a panel of transgenic mouse lines expressing varying levels of homologous PrPC. While breeding true in mice expressing PrPC at near physiological levels, scrapie prions evolve consistently towards different strain components in mice beyond a certain threshold of PrPC overexpression. Our results support the view that PrPC gene dosage can influence prion evolution on homotypic transmission.

SUBMITTER: Le Dur A 

PROVIDER: S-EPMC5264111 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC6954626 | BioStudies
1000-01-01 | S-EPMC470735 | BioStudies
2020-01-01 | S-EPMC7402522 | BioStudies
2008-01-01 | S-EPMC2706533 | BioStudies
2004-01-01 | S-EPMC478560 | BioStudies
1000-01-01 | S-EPMC6113635 | BioStudies
2017-01-01 | S-EPMC5898798 | BioStudies
2016-01-01 | S-EPMC5110189 | BioStudies
1000-01-01 | S-EPMC1500854 | BioStudies
2015-01-01 | S-EPMC4527776 | BioStudies