Dataset Information


Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice.

ABSTRACT: Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. Heme oxygenase-1 (HO-1), the key enzyme in heme degradation, is highly expressed after ICH, but its role is still unclear. In this study, we used an HO-1 inducer and inhibitor to test the role of HO-1 in different stages of ICH in vivo and in vitro. In the early stage of ICH, high HO-1 expression worsened the outcomes of mice subjected to the collagenase-induced ICH model. HO-1 increased brain edema, white matter damage, neuronal death, and neurobehavioral deficits. Furthermore, elevated HO-1 increased inflammation, oxidative stress, matrix metalloproteinase-9/2 activity, and iron deposition. In the later stage of ICH, long-term induction of HO-1 increased hematoma absorption, angiogenesis, and recovery of neurologic function. We conclude that HO-1 activation mediates early brain damage after ICH but promotes neurologic function recovery in the later stage of ICH.


PROVIDER: S-EPMC5363754 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5999006 | BioStudies
1000-01-01 | S-EPMC5429727 | BioStudies
2017-01-01 | S-EPMC5220121 | BioStudies
2016-01-01 | S-EPMC5237112 | BioStudies
2016-01-01 | S-EPMC4977111 | BioStudies
2017-01-01 | S-EPMC5540140 | BioStudies
2020-01-01 | S-EPMC7377845 | BioStudies
1000-01-01 | S-EPMC3078460 | BioStudies
2019-01-01 | S-EPMC6937496 | BioStudies
1000-01-01 | S-EPMC3170939 | BioStudies