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Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection.


ABSTRACT: OBJECTIVE:To determine if immediate compared to deferred initiation of antiretroviral therapy (ART) in healthy persons living with HIV had a more favorable impact on health-related quality of life (QOL), or self-assessed physical, mental, and overall health status. DESIGN:QOL was measured in the Strategic Timing of Antiretroviral Therapy study, which randomized healthy ART-naive persons living with HIV with CD4 cell counts above 500 cells/?l from 35 countries to immediate versus deferred ART. METHODS:At baseline, months 4 and 12, then annually, participants completed a visual analog scale (VAS) for 'perceived current health' and the Short-Form 12-Item Health Survey version 2 from which the following were computed: general health perception; physical component summary (PCS); and mental component summary (MCS); the VAS and general health were rated from 0 (lowest) to 100 (highest). RESULTS:QOL at study entry was high (mean scores: VAS?=?80.9, general health?=?72.5, PCS?=?53.7, MCS?=?48.2). Over a mean follow-up of 3 years, changes in all QOL measures favored the immediate group (P?

SUBMITTER: Lifson AR 

PROVIDER: S-EPMC5373969 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

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