Dataset Information


Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies.

ABSTRACT: A meta-analysis was performed to assess the association of coffee consumption with colorectal cancer and to investigate the shape of the association. Relevant prospective cohort studies were identified by a comprehensive search of the PubMed, Embase and Web of Science databases from their inception through August 2015. Either a random-effects model or fixed-effects model was used to compute the pooled risk estimates when appropriate. Linear and nonlinear dose-response meta-analyses were also performed. Nineteen prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer were included. The risk of colon cancer was decreased by 7% for every 4 cups per day of coffee (RR=0.93, 95%CI, 0.88-0.99; P=0.199). There was a threshold approximately five cups of coffee per day, and the inverse association for colorectal cancer appeared to be stronger at a higher range of intake. However, a nonlinear association of rectal cancer with coffee consumption was not observed (P for nonlinearity = 0.214). In conclusion, coffee consumption is significantly associated with a decreased risk of colorectal cancer at ? 5 cups per day of coffee consumption. The findings support the recommendations of including coffee as a healthy beverage for the prevention of colorectal cancer.


PROVIDER: S-EPMC5386640 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2014-01-01 | S-EPMC3945962 | BioStudies
1000-01-01 | S-EPMC4150007 | BioStudies
| S-EPMC4679527 | BioStudies
2015-01-01 | S-EPMC4576990 | BioStudies
2017-01-01 | S-EPMC5837196 | BioStudies
| S-EPMC4650259 | BioStudies
| S-EPMC7524812 | BioStudies
| S-EPMC6057809 | BioStudies
1000-01-01 | S-EPMC3425971 | BioStudies
1000-01-01 | S-EPMC4004325 | BioStudies