Dataset Information


Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.

ABSTRACT: Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64-1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.


PROVIDER: S-EPMC5421853 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4991460 | BioStudies
2016-01-01 | S-EPMC4888614 | BioStudies
2016-01-01 | S-EPMC4872762 | BioStudies
2016-01-01 | S-EPMC4967224 | BioStudies
2019-01-01 | S-EPMC6636297 | BioStudies
2018-01-01 | S-EPMC6013708 | BioStudies
2008-01-01 | S-EPMC2734972 | BioStudies
2010-01-01 | S-EPMC2893795 | BioStudies
2018-01-01 | S-EPMC6118157 | BioStudies
2016-01-01 | S-EPMC5039395 | BioStudies