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?-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.

ABSTRACT: All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition of breast cancer cell for ER-positive than ER-negative cells, while triple negative breast cancer cell such as MDA-MB-231 cell is poorly responsive to ATRA treatment. In this study, we found that combination of ?-3 free fatty acids (?-3 FFAs) and ATRA exhibited synergistic inhibition of cell growth in three subtypes (ER+ MCF7, HER2+ SK-BR-3, Triple negative HCC1806 and MDA-MB-231 cells) of human breast cancer cell lines. The combined treatment of ?-3 FFAs and ATRA resulted in cell cycle arrest. ?-3 FFAs combined with ATRA synergistically provoked cell apoptosis via the caspase signals but not p53. These findings suggest that combined chemotherapy of ?-3 FFAs with ATRA is beneficial for improvement of ATRA sensitivity in breast cancer cells.

PROVIDER: S-EPMC5462805 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

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