Unknown

Dataset Information

0

Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype.


ABSTRACT: MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

SUBMITTER: Kim HS 

PROVIDER: S-EPMC5462841 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6679025 | BioStudies
1000-01-01 | S-EPMC3198158 | BioStudies
1000-01-01 | S-EPMC5037453 | BioStudies
1000-01-01 | S-EPMC3478659 | BioStudies
2020-01-01 | S-EPMC7646982 | BioStudies
1000-01-01 | S-EPMC5772551 | BioStudies
2015-01-01 | S-EPMC4376689 | BioStudies
2017-01-01 | S-EPMC5554001 | BioStudies
2014-01-01 | S-EPMC3945035 | BioStudies
2006-01-01 | S-EPMC1413743 | BioStudies