Dataset Information


The Implication of Substance P in the Development of Tendinopathy: A Case Control Study.

ABSTRACT: It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and tendinopathy tendon were harvested from human and tenocytes were cultured individually. The expression levels of genes associated with tendinopathy were compared. Next, substance P was exogenously administered to the healthy tenocyte and the effect was evaluated. The results showed that tendinopathy tenocytes had higher levels of COL3A1, MMP1, COX2, SCX, ACTA2, and substance P gene expression compared to healthy tenocytes. Next, substance P treatment on the healthy tenocyte displayed similar changes to that of the tendinopathy tenocytes. These differences between the two groups were also determined by Western blot. Additionally, cells with substance P had the tendinopathy change morphologically although cellular proliferation was significantly higher compared to that of the control group. In conclusion, substance P enhanced cellular proliferation, but concomitantly increased immature collagen (type 3 collagen). Substance P plays a crucial role in tendinopathy development and could be a future therapeutic target for treatment.


PROVIDER: S-EPMC5486064 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6081934 | BioStudies
1000-01-01 | S-EPMC5339827 | BioStudies
2020-01-01 | S-EPMC7304430 | BioStudies
1000-01-01 | S-EPMC4893609 | BioStudies
2014-01-01 | S-EPMC3981497 | BioStudies
2020-01-01 | S-EPMC7406294 | BioStudies
2013-01-01 | S-EPMC3747237 | BioStudies
2018-01-01 | S-EPMC6175495 | BioStudies
2019-01-01 | S-EPMC6387004 | BioStudies
2020-01-01 | S-EPMC7709031 | BioStudies