Unknown

Dataset Information

0

Multi-site and nasal swabbing for carriage of Staphylococcus aureus: what does a single nose swab predict?


ABSTRACT: Carriage of Staphylococcus aureus is a risk for infections. Targeted decolonization reduces postoperative infections but depends on accurate screening.To compare detection of S. aureus carriage in healthy individuals between anatomical sites and nurse- versus self-swabbing; also to determine whether a single nasal swab predicted carriage over four weeks.Healthy individuals were recruited via general practices. After consent, nurses performed multi-site swabbing (nose, throat, and axilla). Participants performed nasal swabbing twice-weekly for four weeks. Swabs were returned by mail and cultured for S. aureus. All S. aureus isolates underwent spa typing. Persistent carriage in individuals returning more than three self-swabs was defined as culture of S. aureus from all or all but one self-swabs.In all, 102 individuals underwent multi-site swabbing; S. aureus carriage was detected from at least one site from 40 individuals (39%). There was no difference between nose (29/102, 28%) and throat (28/102, 27%) isolation rates: the combination increased total detection rate by 10%. Ninety-nine patients returned any self-swab, and 96 returned more than three. Nasal carriage detection was not significantly different on nurse or self-swab [28/99 (74%) vs 26/99 (72%); ?2: P=0.75]. Twenty-two out of 25 participants with first self-swab positive were persistent carriers and 69/71 with first self-swab negative were not, giving high positive predictive value (88%), and very high negative predictive value (97%).Nasal swabs detected the majority of carriage; throat swabs increased detection by 10%. Self-taken nasal swabs were equivalent to nurse-taken swabs and predicted persistent nasal carriage over four weeks.

SUBMITTER: Young BC 

PROVIDER: S-EPMC5490851 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2014-01-01 | S-EPMC4216860 | BioStudies
2014-01-01 | S-EPMC4213029 | BioStudies
2017-01-01 | S-EPMC5431815 | BioStudies
2021-01-01 | S-EPMC7849480 | BioStudies
2019-01-01 | S-EPMC6611591 | BioStudies
2016-01-01 | S-EPMC5112983 | BioStudies
2016-01-01 | S-EPMC5023121 | BioStudies
2013-01-01 | S-EPMC3806823 | BioStudies
1000-01-01 | S-EPMC4316926 | BioStudies
2015-01-01 | S-EPMC4309706 | BioStudies