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Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.


ABSTRACT: Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

SUBMITTER: Fabisiak A 

PROVIDER: S-EPMC5503283 | BioStudies | 2017-01-01

SECONDARY ACCESSION(S): NCT01908465

REPOSITORIES: biostudies

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