Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.
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ABSTRACT: Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.
SUBMITTER: Fabisiak A
PROVIDER: S-EPMC5503283 | BioStudies | 2017-01-01
SECONDARY ACCESSION(S): NCT01908465
REPOSITORIES: biostudies
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