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A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids.


ABSTRACT: A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl N-phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5560440 | BioStudies | 2016-01-01

REPOSITORIES: biostudies

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