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K-t accelerated aortic 4D flow MRI in under two minutes: Feasibility and impact of resolution, k-space sampling patterns, and respiratory navigator gating on hemodynamic measurements.


ABSTRACT: PURPOSE:To assess the performance of highly accelerated free-breathing aortic four-dimensional (4D) flow MRI acquired in under 2 minutes compared to conventional respiratory gated 4D flow. METHODS:Eight k-t accelerated nongated 4D flow MRI (parallel MRI with extended and averaged generalized autocalibrating partially parallel acquisition kernels [PEAK GRAPPA], R?=?5, TRes?=?67.2 ms) using four ky -kz Cartesian sampling patterns (linear, center-out, out-center-out, random) and two spatial resolutions (SRes1?= 3.5?×?2.3?×?2.6?mm3 , SRes2?=?4.5?×?2.3?× 2.6?mm3 ) were compared in vitro (aortic coarctation flow phantom) and in 10 healthy volunteers, to conventional 4D flow (16?mm-navigator acceptance window; R?=?2; TRes?=?39.2 ms; SRes?= 3.2?× 2.3?×?2.4?mm3 ). The best k-t accelerated approach was further assessed in 10 patients with aortic disease. RESULTS:The k-t accelerated in vitro aortic peak flow (Qmax), net flow (Qnet), and peak velocity (Vmax) were lower than conventional 4D flow indices by ?4.7%,???11%, and ?22%, respectively. In vivo k-t accelerated acquisitions were significantly shorter but showed a trend to lower image quality compared to conventional 4D flow. Hemodynamic indices for linear and out-center-out k-space samplings were in agreement with conventional 4D flow (Qmax???13%, Qnet???13%, Vmax???17%, P?>?0.05). CONCLUSION:Aortic 4D flow MRI in under 2 minutes is feasible with moderate underestimation of flow indices. Differences in k-space sampling patterns suggest an opportunity to mitigate image artifacts by an optimal trade-off between scan time, acceleration, and k-space sampling. Magn Reson Med 79:195-207, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Bollache E 

PROVIDER: S-EPMC5589472 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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