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MassPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.


ABSTRACT: INTRODUCTION:Mass spectrometry imaging (MSI) experiments result in complex multi-dimensional datasets, which require specialist data analysis tools. OBJECTIVES:We have developed massPix-an R package for analysing and interpreting data from MSI of lipids in tissue. METHODS:massPix produces single ion images, performs multivariate statistics and provides putative lipid annotations based on accurate mass matching against generated lipid libraries. RESULTS:Classification of tissue regions with high spectral similarly can be carried out by principal components analysis (PCA) or k-means clustering. CONCLUSION:massPix is an open-source tool for the analysis and statistical interpretation of MSI data, and is particularly useful for lipidomics applications.

PROVIDER: S-EPMC5608769 | BioStudies |

REPOSITORIES: biostudies

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