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Controlling the activity of quorum sensing autoinducers with light.


ABSTRACT: Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.

SUBMITTER: Van der Berg JP 

PROVIDER: S-EPMC5659144 | BioStudies | 2015-01-01T00:00:00Z

REPOSITORIES: biostudies

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