Dataset Information


Tea polyphenols ameliorate fat storage induced by high-fat diet in Drosophila melanogaster.



Polyphenols in tea are considered beneficial to human health. However, many such claims of their bioactivity still require in vitro and in vivo evidence.


Using Drosophila melanogaster as a model multicellular organism, we assess the fat accumulation-suppressing effects of theaflavin (TF), a tea polyphenol; epitheaflagallin (ETG), which has an unknown function; and epigallocatechin gallate (EGCg), a prominent component of green tea. Dietary TF reduced the malondialdehyde accumulation related to a high-fat diet in adult flies. Other physiological and genetic responses induced by the high-fat diet, such as lipid accumulation in the fat body and expression of lipid metabolism-related genes, were ameliorated by the addition of TF, ETG, and EGCg, in some cases approaching respective levels without high-fat diet exposure. Continuous ingestion of the three polyphenols resulted in a shortened lifespan.


We provide evidence in Drosophila that tea polyphenols have a fat accumulation-suppressing effect that has received recent attention. We also suggest that tea polyphenols can provide different desirable biological activities depending on their composition and the presence or absence of other chemical components.

SUBMITTER: Kayashima Y 

PROVIDER: S-EPMC5669444 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4636172 | BioStudies
2020-01-01 | S-EPMC7367004 | BioStudies
2021-01-01 | S-EPMC7682485 | BioStudies
2019-01-01 | S-EPMC6667385 | BioStudies
1000-01-01 | S-EPMC6030063 | BioStudies
2013-01-01 | S-EPMC4889458 | BioStudies
2012-01-01 | S-EPMC3303150 | BioStudies
2012-01-01 | S-EPMC3538623 | BioStudies
2018-01-01 | S-EPMC6350933 | BioStudies
2018-01-01 | S-EPMC5854642 | BioStudies