Dataset Information


Altered Patterns of Early Metabolic Decompensation in Type 1 Diabetes During Treatment with a SGLT2 Inhibitor: An Insulin Pump Suspension Study.

ABSTRACT: BACKGROUND:Enthusiasm for the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as an adjunctive treatment in type 1 diabetes (T1D) has been offset by the possible increased risk of diabetic ketoacidosis (DKA). Since pump-treated T1D patients are susceptible to DKA due to infusion site problems, this study was undertaken to assess how treatment with SGLT2i affects patterns of early metabolic decompensation following suspension of basal insulin. METHODS:Ten T1D participants (age 19-35 years, duration 10?±?8 years, A1c 7.4%?±?0.8%) underwent overnight pump suspension studies before and after treatment with canagliflozin (CANA). On both nights, basal insulin was suspended at 3 AM and plasma glucose (PG), ?-hydroxybutyrate (BHB), free fatty acids (FFA), plasma insulin (PI), and glucagon were measured. Studies were terminated 6?h after suspension or if PG rose to >350?mg/dL or BHB >2.5?mmol/L. RESULTS:PI levels at the start of suspension were reduced by 30% after CANA treatment (44?±?11?uU/mL vs. 31?±?10?uU/mL, P?

PROVIDER: S-EPMC5689123 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC6434586 | BioStudies
| S-EPMC6483601 | BioStudies
| S-EPMC7679772 | BioStudies
| S-EPMC5272181 | BioStudies
| S-EPMC6448958 | BioStudies
| S-EPMC6916409 | BioStudies
2020-04-16 | GSE148702 | GEO
| S-EPMC7576419 | BioStudies
| S-EPMC6592972 | BioStudies
| S-EPMC3292336 | BioStudies