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Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.


ABSTRACT: Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.

SUBMITTER: Sze A 

PROVIDER: S-EPMC5691638 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

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