Dataset Information


Similarities between acylcarnitine profiles in large for gestational age newborns and obesity.

ABSTRACT: Large for gestational age (LGA) newborns have an increased risk of obesity, insulin resistance, and metabolic syndrome. Acylcarnitine profiles in obese children and adults are characterized by increased levels of C3, C5, and certain medium-chain (C12) and long-chain (C14:1 and C16) acylcarnitines. C2 is also increased in insulin-resistant states. In this 1-year observational study of 2514 newborns (246 LGA newborns, 250 small for gestational age (GA) newborns, and 2018 appropriate for GA newborns), we analyzed and compared postnatal acylcarnitine profiles in LGA newborns with profiles described for obese individuals. Acylcarnitine analysis was performed by tandem mass spectrometry on dried-blood spots collected on day 3 of life. LGA newborns had higher levels of total short-chain acylcarnitines (p?

SUBMITTER: Sanchez-Pintos P 

PROVIDER: S-EPMC5701125 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4729603 | BioStudies
2019-01-01 | S-EPMC6383405 | BioStudies
2016-01-01 | S-EPMC5122780 | BioStudies
2018-01-01 | S-EPMC6057484 | BioStudies
2018-01-01 | S-EPMC5994672 | BioStudies
2013-01-01 | S-EPMC3874609 | BioStudies
1000-01-01 | S-EPMC5814600 | BioStudies
2021-04-28 | MTBLS2376 | MetaboLights
1000-01-01 | S-EPMC2714383 | BioStudies
1000-01-01 | S-EPMC4285541 | BioStudies