Dataset Information


Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study.

ABSTRACT: Background:Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the pre-existing antibodies to Bordetella pertussis antigens in a cohort of 90 pregnant women. Methods:We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA). Results:When values of >10 IU/ml were accepted as potential protective concentrations, we found that the percentages of unprotected infants were 73.3%, 43.3% and 75.5% for anti-PT, anti-FHA and anti-PRN IgG, respectively. Discussion:These results may explain the susceptibility for pertussis among newborn infants in Thailand and support the requirement for a pertussis booster vaccine during pregnancy, which may contribute to the passive seroprotection among newborns during the first months of life.

PROVIDER: S-EPMC5702505 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC8010450 | BioStudies
2016-01-01 | S-EPMC5106623 | BioStudies
| S-EPMC5711396 | BioStudies
| S-EPMC6422512 | BioStudies
| S-EPMC8447829 | BioStudies
| S-EPMC8412870 | BioStudies
| S-EPMC8426785 | BioStudies
| S-EPMC3349578 | BioStudies
| S-EPMC7446907 | BioStudies
| S-EPMC5287315 | BioStudies