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Time to first positive HIV-1 DNA PCR may differ with antiretroviral regimen in infants infected with non-B subtype HIV-1.


ABSTRACT: OBJECTIVE:To evaluate the association of type and timing of prophylactic maternal and infant antiretroviral regimen with time to first positive HIV-1 DNA PCR test, in nonbreastfed HIV-infected infants, from populations infected predominantly with HIV-1 non-B subtype virus. DESIGN:Analysis of combined data on nonbreastfed HIV-infected infants from prospective cohorts in Botswana, Thailand, and the United Kingdom (N?=?405). METHODS:Parametric models appropriate for interval-censored outcomes estimated the time to first positive PCR according to maternal or infant antiretroviral regimen category and timing of maternal antiretroviral initiation, with adjustment for covariates. RESULTS:Maternal antiretroviral regimens included: no antiretrovirals (n?=?138), single-nucleoside analog reverse transcriptase inhibitor (n?=?165), single-dose nevirapine with zidovudine (n?=?66), and combination prophylaxis with 3 or more antiretrovirals [combination antiretroviral therapy (cART), n?=?36]. Type of maternal/infant antiretroviral regimen and timing of maternal antiretroviral initiation were each significantly associated with time to first positive PCR (multivariate P?

SUBMITTER: Balasubramanian R 

PROVIDER: S-EPMC5710822 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

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