Unknown

Dataset Information

0

Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population.


ABSTRACT: Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between CAV-1 polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in CAV-1 using the Sequenom MassARRAY method. The association between CAV-1genotypes and BC risk was assessed in six genetic models by calculating the odds ratio (OR) and 95% confidence intervals (95% CIs) with ?2-test. The CAV-1 rs3807987 polymorphism was observed to increase the risk of BC And the A allele of rs3807987 relates to a larger tumor size (?2cm) and lower incidence of PR-positive BC while the AA genotype of rs7804372 associates with a higher ER and Her-2 positive rate among BC patients. In addition, Ars1997623Grs3807987Trs7804372 haplotype was linked to a decreased risk of BC (OR =0.64, 95%CI=0.44-0.93), whereas Crs1997623Ars3807987Trs7804372 haplotype was related to an increased BC risk (OR =1.74, 95%CI=1.04-2.92). Our study suggests that CAV-1 rs3807987 can increase the BC risk among Chinese Han women. And the rs3807987 and rs7804372 in CAV-1 may serve as predictors for prognosis of BC.

SUBMITTER: Wang M 

PROVIDER: S-EPMC5710954 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5367681 | BioStudies
2010-01-01 | S-EPMC2999679 | BioStudies
2012-01-01 | S-EPMC3504019 | BioStudies
2018-01-01 | S-EPMC6128940 | BioStudies
2013-01-01 | S-EPMC3873991 | BioStudies
2020-01-01 | S-EPMC7284033 | BioStudies
2018-01-01 | S-EPMC5856390 | BioStudies
2016-01-01 | S-EPMC5342380 | BioStudies
2016-01-01 | S-EPMC5349947 | BioStudies
2019-01-01 | S-EPMC6936049 | BioStudies