Dataset Information


Evidence for a task-dependent switch in subthalamo-nigral basal ganglia signaling.

ABSTRACT: Basal ganglia (BG) can either facilitate or inhibit movement through excitatory and inhibitory pathways; however whether these opposing signals are dynamically regulated during healthy behavior is not known. Here, we present compelling neurophysiological evidence from three complimentary experiments in non-human primates, indicating task-specific changes in tonic BG pathway weightings during saccade behavior with different cognitive demands. First, simultaneous local field potential recording in the subthalamic nucleus (STN; BG input) and substantia nigra pars reticulata (SNr; BG output) reveals task-dependent shifts in subthalamo-nigral signals. Second, unilateral electrical stimulation of the STN, SNr, and caudate nucleus results in strikingly different saccade directionality and latency biases across the BG. Third, a simple artificial neural network representing canonical BG signaling pathways suggests that pathway weightings can be altered by cortico-BG input activation. Overall, inhibitory pathways (striato-pallidal-subthalamo-nigral) dominate during goal-driven behavior with instructed rewards, while facilitatory pathways (striato-nigral and subthalamo-pallidal-nigral) dominate during unconstrained (free reward) conditions.


PROVIDER: S-EPMC5715140 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2012-01-01 | S-EPMC3407058 | BioStudies
2013-01-01 | S-EPMC3656753 | BioStudies
2017-01-01 | S-EPMC5679443 | BioStudies
2008-01-01 | S-EPMC2585637 | BioStudies
2019-01-01 | S-EPMC6451076 | BioStudies
2019-01-01 | S-EPMC6382172 | BioStudies
1000-01-01 | S-EPMC4005946 | BioStudies
2010-01-01 | S-EPMC2853273 | BioStudies
2020-01-01 | S-EPMC7380975 | BioStudies
2011-01-01 | S-EPMC3205029 | BioStudies