Dataset Information


Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae.

ABSTRACT: Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resistance. Here, we show the increased prevalence of Klebsiella pneumoniae lipopolysaccharide O2 serotype strains in all major drug resistance groups correlating with a paucity of anti-O2 antibodies in human B cell repertoires. We identify human monoclonal antibodies to O-antigens that are highly protective in mouse models of infection, even against heavily encapsulated strains. These antibodies, including a rare anti-O2 specific antibody, synergistically protect against drug-resistant strains in adjunctive therapy with meropenem, a standard-of-care antibiotic, confirming the importance of immune assistance in antibiotic therapy. These findings support an antibody-based immunotherapeutic strategy even for highly resistant K. pneumoniae infections, and underscore the effect humoral immunity has on evolving drug resistance.

PROVIDER: S-EPMC5722860 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC8726669 | BioStudies
| S-EPMC7303279 | BioStudies
| S-EPMC6314524 | BioStudies
| S-EPMC8348552 | BioStudies
| S-EPMC3165360 | BioStudies
| S-EPMC6480354 | BioStudies
| S-EPMC8479884 | BioStudies
| S-EPMC7927857 | BioStudies
| S-EPMC6929480 | BioStudies
| S-EPMC4182774 | BioStudies