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Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c-terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients.

ABSTRACT: Iron deficiency stimulates fibroblast growth factor 23 (FGF23) transcription. This study aimed to determine whether oral ferrous iron (Fe2+ ) reduces the serum FGF23 levels of iron-deficient maintenance haemodialysis (MHD) patients in the same way as oral ferric iron (Fe3+ ) METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study. Patients who had taken iron supplements during the 8?weeks before the study were excluded. The patients' iron stores and their serum FGF23, phosphate, intact parathyroid hormone (iPTH), albumin, C-reactive protein (CRP), and albumin-adjusted calcium (Ca) levels were examined at the baseline and after 3?months' treatment with sodium ferrous citrate (Fe2+ ).The patients' transferrin saturation values and serum iron and ferritin levels were significantly increased after 3?months' treatment (P?

SUBMITTER: Yamashita K 

PROVIDER: S-EPMC5725691 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

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