Dataset Information


Self-reported sleep duration and napping, cardiac risk factors and markers of subclinical vascular disease: cross-sectional study in older men.

ABSTRACT: STUDYOBJECTIVES:Daytime sleep has been associated with increased risk of cardiovascular disease and heart failure (HF), but the mechanisms remain unclear. We have investigated the association between daytime and night-time sleep patterns and cardiovascular risk markers in older adults including cardiac markers and subclinical markers of atherosclerosis (arterial stiffness and carotid intima-media thickness (CIMT)). METHODS:Cross-sectional study of 1722 surviving men aged 71-92 examined in 2010-2012 across 24 British towns from a prospective study initiated in 1978-1980. Participants completed a questionnaire and were invited for a physical examination. Men with a history of heart attack or HF (n=251) were excluded from the analysis. RESULTS:Self-reported daytime sleep duration was associated with higher fasting glucose and insulin levels (p=0.02?and p=0.01, respectively) even after adjustment for age, body mass index, physical activity and social class. Compared with those with no daytime sleep, men with daytime sleep >1?hour, defined as excessive daytime sleepiness (EDS), had a higher risk of raised N-terminal pro-brain natriuretic peptide of ?400?pg/mL, the diagnostic threshold for HF (OR (95%?CI)=1.88 (1.15 to 3.1)), higher mean troponin, reduced lung function (forced expiratory volume in 1 s) and elevated von Willebrand factor, a marker of endothelial dysfunction. However, EDS was unrelated to CIMT and arterial stiffness. By contrast, night-time sleep was only associated with HbA1c (short or long sleep) and arterial stiffness (short sleep). CONCLUSIONS:Daytime sleep duration of >1?hour may be an early indicator of HF.


PROVIDER: S-EPMC5726087 | BioStudies | 2017-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6584676 | BioStudies
2014-01-01 | S-EPMC4110191 | BioStudies
2013-01-01 | S-EPMC3724779 | BioStudies
2019-01-01 | S-EPMC6690780 | BioStudies
2020-01-01 | S-EPMC7792372 | BioStudies
2014-01-01 | S-EPMC4157859 | BioStudies
2019-01-01 | S-EPMC7445829 | BioStudies
1000-01-01 | S-EPMC4335535 | BioStudies
2017-01-01 | S-EPMC5380148 | BioStudies
2013-01-01 | S-EPMC3865121 | BioStudies